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Some frequent damaging consequences of high temperature include reduced germination and biomass, increased tillering, chlorosis, necrosis, early senescence of floral buds, premature mortality, and fruit senescence

The first indication of a problem is typically a clinical one injection site reaction, fever, or worse

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For malabsorption (e.g., pernicious anemia), injections are often preferred, though some clinicians still use very high-dose oral regimens (NIH ODS)